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Synthesis of multicyclic pyridine and quinoline derivatives via intramolecular C-H bond functionalization.

ABSTRACT: An efficient method is reported for the preparation of multicyclic pyridines and quinolines by a rhodium-catalyzed intramolecular C-H bond functionalization process. The method shows good scope for branched and unbranched alkyl substituents on the pyridine ring and at the R position of the tethered alkene group. Starting materials capable of undergoing olefin isomerization to provide terminal 1,1-disubstituted alkenes also proved to be effective substrates.

SUBMITTER: Yotphan S 

PROVIDER: S-EPMC2892546 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Synthesis of multicyclic pyridine and quinoline derivatives via intramolecular C-H bond functionalization.

Yotphan Sirilata S   Bergman Robert G RG   Ellman Jonathan A JA  

Organic letters 20100701 13

An efficient method is reported for the preparation of multicyclic pyridines and quinolines by a rhodium-catalyzed intramolecular C-H bond functionalization process. The method shows good scope for branched and unbranched alkyl substituents on the pyridine ring and at the R position of the tethered alkene group. Starting materials capable of undergoing olefin isomerization to provide terminal 1,1-disubstituted alkenes also proved to be effective substrates. ...[more]

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