Ontology highlight
ABSTRACT:
SUBMITTER: Cosgrove MS
PROVIDER: S-EPMC2892832 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Cosgrove Michael S MS Patel Anamika A
The FEBS journal 20100304 8
Several acute lymphoblastic and myelogenous leukemias are correlated with alterations in the human mixed lineage leukemia protein-1 (MLL1) gene. MLL1 is a member of the evolutionarily conserved SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, which are required for the regulation of distinct groups of developmentally regulated genes in metazoans. Despite the important biological role of SET1 family enzymes and their involvement in human leukemias, relatively little is understood abo ...[more]