Hormonal regulation of cardiac KCNE2 gene expression.
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ABSTRACT:
SUBMITTER: Kundu P
PROVIDER: S-EPMC2893227 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Hormonal regulation of cardiac KCNE2 gene expression.
Kundu Pallob P Ciobotaru Andrea A Foroughi Sina S Toro Ligia L Stefani Enrico E Eghbali Mansoureh M
Molecular and cellular endocrinology 20080619 1-2
The KCNE2 gene encodes a single transmembrane domain protein that modulates a variety of K+ channel functions in various tissues. Here we show that cardiac KCNE2 transcript levels are approximately 10-fold upregulated at the end of pregnancy. This upregulation was mimicked by 17-beta estradiol but not by 5alpha-dihydrotestosterone treatments in ovariectomized mice. To investigate the mechanism of KCNE2 transcriptional regulation by estrogen, we experimentally identified KCNE2 transcription start ...[more]
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