Biomimetic hybrid scaffolds for engineering human tooth-ligament interfaces.
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ABSTRACT:
SUBMITTER: Park CH
PROVIDER: S-EPMC2893240 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Biomimetic hybrid scaffolds for engineering human tooth-ligament interfaces.
Park Chan Ho CH Rios Hector F HF Jin Qiming Q Bland Megan E ME Flanagan Colleen L CL Hollister Scott J SJ Giannobile William V WV
Biomaterials 20100514 23
A major clinical challenge in the reconstruction of large oral and craniofacial defects is the neogenesis of osseous and ligamentous interfacial structures. Currently, oral regenerative medicine strategies are unpredictable for repair of tooth-supporting tissues destroyed as a consequence of trauma, chronic infection or surgical resection. Here, we demonstrate multi-scale computational design and fabrication of composite hybrid polymeric scaffolds for targeted cell transplantation of genetically ...[more]
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