Ontology highlight
ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC2893267 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Zhu Xinmei X Fallert-Junecko Beth A BA Fujita Mitsugu M Ueda Ryo R Kohanbash Gary G Kastenhuber Edward R ER McDonald Heather A HA Liu Yan Y Kalinski Pawel P Reinhart Todd A TA Salazar Andres M AM Okada Hideho H
Cancer immunology, immunotherapy : CII 20100612 9
Stimulation of double-stranded (ds)RNA receptors can increase the effectiveness of cancer vaccines, but the underlying mechanisms are not completely elucidated. In this study, we sought to determine critical roles of host IFN-alpha and IFN-gamma pathways in the enhanced therapeutic efficacy mediated by peptide vaccines and polyinosinic-polycytidylic acid [poly(I:C)] stabilized by lysine and carboxymethylcellulose (poly-ICLC) in the murine central nervous system (CNS) GL261 glioma. C57BL/6-backgr ...[more]