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Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component.

ABSTRACT: Recent studies in Drosophila identified pygopus, which encodes a PHD finger protein, as an additional nuclear component of the canonical Wingless(Wg)/Wnt signaling pathway. In this study, we describe the molecular cloning and expression analysis of a mouse pygopus gene, mpygo2. mpygo2 transcripts were detected in almost all adult mouse tissues examined, whereas transcripts of another mouse pygopus gene, mpygo1, were detected only in heart tissue. Abundant mpygo2 transcripts were observed during embryogenesis in multiple developmental sites. Consistent with the demonstrated role of the Wnt-beta-catenin-LEF/TCF signaling pathway in mammalian skin development, mpygo2 expression was detected in the developing epidermis and hair follicles, which suggests that mpygo2 might mediate the effect of this signaling pathway in mouse skin.

SUBMITTER: Li B

PROVIDER: S-EPMC2893388 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature

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Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component.

Li Baoan B Mackay Douglas R DR Ma Ji J Dai Xing X

Genomics 20040801 2

Recent studies in Drosophila identified pygopus, which encodes a PHD finger protein, as an additional nuclear component of the canonical Wingless(Wg)/Wnt signaling pathway. In this study, we describe the molecular cloning and expression analysis of a mouse pygopus gene, mpygo2. mpygo2 transcripts were detected in almost all adult mouse tissues examined, whereas transcripts of another mouse pygopus gene, mpygo1, were detected only in heart tissue. Abundant mpygo2 transcripts were observed during ...[more]

PMID: 15234002

Similar Datasets

Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling.

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| S-EPMC3871875 | biostudies-literature

Downregulation of Pygopus 2 inhibits vascular mimicry in glioma U251 cells by suppressing the canonical Wnt signaling pathway.

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Cloning and developmental expression of zebrafish pdzrn3.

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A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.

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Cloning and characterization of a putative mouse acetyl-CoA transporter cDNA.

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| S-EPMC7127759 | biostudies-literature

Ectopic expression of mouse Sry interferes with Wnt/beta-catenin signaling in mouse embryonal carcinoma cell lines.

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| S-EPMC2637177 | biostudies-literature

Integrated analysis of Wnt signalling system component gene expression.

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| S-EPMC3193219 | biostudies-literature

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