Ontology highlight
ABSTRACT:
SUBMITTER: Hassanein MT
PROVIDER: S-EPMC2893809 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Hassanein Mohamed T MT Lyon Helen N HN Nguyen Thutrang T TT Akylbekova Ermeg L EL Waters Kevin K Lettre Guillaume G Tayo Bamidele B Forrester Terrence T Sarpong Daniel F DF Stram Dan O DO Butler Johannah L JL Wilks Rainford R Liu Jiankang J Le Marchand Loic L Kolonel Laurence N LN Zhu Xiaofeng X Henderson Brian B Cooper Richard R McKenzie Colin C Taylor Herman A HA Haiman Christopher A CA Hirschhorn Joel N JN
Human molecular genetics 20100429 14
Genome-wide association studies have identified many common genetic variants that are associated with polygenic traits, and have typically been performed with individuals of recent European ancestry. In these populations, many common variants are tightly correlated, with the perfect or near-perfect proxies for the functional or true variant showing equivalent evidence of association, considerably limiting the resolution of fine mapping. Populations with recent African ancestry often have less ex ...[more]