Ontology highlight
ABSTRACT:
SUBMITTER: Shih AY
PROVIDER: S-EPMC2893883 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Shih Andy Y AY Friedman Beth B Drew Patrick J PJ Tsai Philbert S PS Lyden Patrick D PD Kleinfeld David D
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090128 4
Pial arterioles actively change diameter to regulate blood flow to the cortex. However, it is unclear whether arteriole reactivity and its homeostatic role of conserving red blood cell (RBC) flux remains intact after a transient period of ischemia. To examine this issue, we measured vasodynamics in pial arteriole networks that overlie the stroke penumbra during transient middle cerebral artery occlusion in rat. In vivo two-photon laser-scanning microscopy was used to obtain direct and repeated m ...[more]