Ontology highlight
ABSTRACT:
SUBMITTER: Charest PG
PROVIDER: S-EPMC2893887 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Charest Pascale G PG Shen Zhouxin Z Lakoduk Ashley A Sasaki Atsuo T AT Briggs Steven P SP Firtel Richard A RA
Developmental cell 20100501 5
Ras was found to regulate Dictyostelium chemotaxis, but the mechanisms that spatially and temporally control Ras activity during chemotaxis remain largely unknown. We report the discovery of a Ras signaling complex that includes the Ras guanine exchange factor (RasGEF) Aimless, RasGEFH, protein phosphatase 2A (PP2A), and a scaffold designated Sca1. The Sca1/RasGEF/PP2A complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading ed ...[more]