Ontology highlight
ABSTRACT:
SUBMITTER: Geng J
PROVIDER: S-EPMC2893989 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Geng Jiefei J Nair Usha U Yasumura-Yorimitsu Kyoko K Klionsky Daniel J DJ
Molecular biology of the cell 20100505 13
In eukaryotic cells, autophagy mediates the degradation of cytosolic contents in response to environmental change. Genetic analyses in fungi have identified over 30 autophagy-related (ATG) genes and provide substantial insight into the molecular mechanism of this process. However, one essential issue that has not been resolved is the origin of the lipids that form the autophagosome, the sequestering vesicle that is critical for autophagy. Here, we report that two post-Golgi proteins, Sec2 and Se ...[more]