Ontology highlight
ABSTRACT:
SUBMITTER: Le ON
PROVIDER: S-EPMC2894262 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Le Oanh N L ON Rodier Francis F Fontaine Francois F Coppe Jean-Philippe JP Campisi Judith J DeGregori James J Laverdière Caroline C Kokta Victor V Haddad Elie E Beauséjour Christian M CM
Aging cell 20100313 3
Exposure to IR has been shown to induce the formation of senescence markers, a phenotype that coincides with lifelong delayed repair and regeneration of irradiated tissues. We hypothesized that IR-induced senescence markers could persist long-term in vivo, possibly contributing to the permanent reduction in tissue functionality. Here, we show that mouse tissues exposed to a sublethal dose of IR display persistent (up to 45 weeks, the maximum time analyzed) DNA damage foci and increased p16(INK4a ...[more]