Ontology highlight
ABSTRACT:
SUBMITTER: Cai S
PROVIDER: S-EPMC2895821 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Cai Shang S O'Connell Christopher B CB Khodjakov Alexey A Walczak Claire E CE
Nature cell biology 20090614 7
Proper chromosome congression (the process of aligning chromosomes on the spindle) contributes to accurate and faithful chromosome segregation. It is widely accepted that congression requires kinetochore fibres (K-fibres), microtubule bundles that extend from the kinetochores to spindle poles. Here, we demonstrate that chromosomes in human cells co-depleted of HSET (human kinesin-14) and hNuf2 (human Ndc80/Hec1-complex component) can congress to the metaphase plate in the absence of K-fibres. Ho ...[more]