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YLoc--an interpretable web server for predicting subcellular localization.

ABSTRACT: Predicting subcellular localization has become a valuable alternative to time-consuming experimental methods. Major drawbacks of many of these predictors is their lack of interpretability and the fact that they do not provide an estimate of the confidence of an individual prediction. We present YLoc, an interpretable web server for predicting subcellular localization. YLoc uses natural language to explain why a prediction was made and which biological property of the protein was mainly responsible for it. In addition, YLoc estimates the reliability of its own predictions. YLoc can, thus, assist in understanding protein localization and in location engineering of proteins. The YLoc web server is available online at www.multiloc.org/YLoc.

SUBMITTER: Briesemeister S

PROVIDER: S-EPMC2896088 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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YLoc--an interpretable web server for predicting subcellular localization.

Briesemeister Sebastian S Rahnenführer Jörg J Kohlbacher Oliver O

Nucleic acids research 20100527 Web Server issue

Predicting subcellular localization has become a valuable alternative to time-consuming experimental methods. Major drawbacks of many of these predictors is their lack of interpretability and the fact that they do not provide an estimate of the confidence of an individual prediction. We present YLoc, an interpretable web server for predicting subcellular localization. YLoc uses natural language to explain why a prediction was made and which biological property of the protein was mainly responsib ...[more]

PMID: 20507917

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