Ontology highlight
ABSTRACT:
SUBMITTER: Tan K
PROVIDER: S-EPMC2896259 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Tan Kemin K Duquette Mark M Liu Jin-Huan JH Zhang Rongguang R Joachimiak Andrzej A Wang Jia-huai JH Lawler Jack J
Structure (London, England : 1993) 20060101 1
The N-terminal domain of thrombospondin-1 (TSPN-1) mediates the protein's interaction with (1) glycosaminoglycans, calreticulin, and integrins during cellular adhesion, (2) low-density lipoprotein receptor-related protein during uptake and clearance, and (3) fibrinogen during platelet aggregation. The crystal structure of TSPN-1 to 1.8 A resolution is a beta sandwich with 13 antiparallel beta strands and 1 irregular strand-like segment. Unique structural features of the N- and C-terminal regions ...[more]