Ontology highlight
ABSTRACT:
SUBMITTER: Avissar-Whiting M
PROVIDER: S-EPMC2896875 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Avissar-Whiting Michele M Veiga Keila R KR Uhl Kristen M KM Maccani Matthew A MA Gagne Luc A LA Moen Erika L EL Marsit Carmen J CJ
Reproductive toxicology (Elmsford, N.Y.) 20100424 4
Exposure to bisphenol A (BPA) has been observed to alter developmental pathways and cell processes, at least in part, through epigenetic mechanisms. This study sought to investigate the effect of BPA on microRNAs (miRNAs) in human placental cells. miRNA microarray was performed following BPA treatment in three immortalized cytotrophoblast cell lines and the results validated using quantitative real-time PCR. For functional analysis, overexpression constructs were stably transfected into cells th ...[more]