Nucleosome occupancy landscape and dynamics at mouse recombination hotspots.
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ABSTRACT:
SUBMITTER: Getun IV
PROVIDER: S-EPMC2897116 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Nucleosome occupancy landscape and dynamics at mouse recombination hotspots.
Getun Irina V IV Wu Zhen K ZK Khalil Ahmad M AM Bois Philippe R J PR
EMBO reports 20100528 7
During meiosis, paternal and maternal homologous chromosomes recombine at specific recombination sites named hotspots. What renders 2% of the mammalian genomes permissive to meiotic recombination by allowing Spo11 endonuclease to initiate double-strand breaks is largely unknown. Work in yeast has shown that chromatin accessibility seems to be important for this activity. Here, we define nucleosome profiles and dynamics at four mouse recombination hotspots by purifying highly enriched fractions o ...[more]
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