Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC2897250 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Zhang Shuliu S Bovshik Evgeniy I EI Maillard Rodrigo R Gromowski Gregory D GD Volk David E DE Schein Catherine H CH Huang Claire Y-H CY Gorenstein David G DG Lee James C JC Barrett Alan D T AD Beasley David W C DW
Virology 20100506 1
Site-directed mutagenesis of residues in the BC loop (residues 329-333) of the envelope (E) protein domain III in a West Nile virus (WNV) infectious clone and in plasmids encoding recombinant WNV and dengue type 2 virus domain III proteins demonstrated a critical role for residues in this loop in the function and antigenicity of the E protein. This included a strict requirement for the tyrosine at residue 329 of WNV for virus viability and E domain III folding. The absence of an equivalent resid ...[more]