Ontology highlight
ABSTRACT:
SUBMITTER: Furihata T
PROVIDER: S-EPMC2897278 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20100426 7
Concentrative nucleoside transporter 2 (CNT2) (encoded by the SLC28A2 gene) transports various antiviral or antitumor purine nucleoside analogs to be involved in their pharmacokinetics and pharmacological actions. The results of our study showed that mouse hepatocytes hardly expressed CNT2 mRNA and no CNT2-dependent nucleoside uptake was observed, while rat hepatocytes exhibited high CNT2-dependent nucleoside uptake activity levels with abundant CNT2 mRNA expression. We concluded that CNT2 contr ...[more]