ISEcp1-mediated transposition and homologous recombination can explain the context of bla(CTX-M-62) linked to qnrB2.
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ABSTRACT:
SUBMITTER: Zong Z
PROVIDER: S-EPMC2897309 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
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ISEcp1-mediated transposition and homologous recombination can explain the context of bla(CTX-M-62) linked to qnrB2.
Zong Zhiyong Z Partridge Sally R SR Iredell Jonathan R JR
Antimicrobial agents and chemotherapy 20100426 7
bla(CTX-M-62), a C508T variant of bla(CTX-M-3b), was transferred from Klebsiella pneumoniae JIE137 on a conjugative plasmid together with a class 1 integron containing the dfrA12-gcuF-aadA2 cassette array, ISCR1, and qnrB2. bla(CTX-M-62) lies between intact and rearranged copies of ISEcp1 in a configuration that can be explained by a combination of transposition and homologous recombination and which also illustrates the ability of ISEcp1 to mobilize an adjacent gene as part of transposition uni ...[more]
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