A natural ribozyme with 3',5' RNA ligase activity.
Ontology highlight
ABSTRACT: Using electrophoresis, sequencing and enzymatic digestion, we show that the group I intron from the cyanobacterium Anabaena sp. PCC 7120 catalyzes phosphodiester bond formation using a triphosphate on the 5'-terminal nucleotide, much like protein polymerases and engineered ribozymes. In the process, this ribozyme forms a unique circular RNA that incorporates the exogenous guanosine cofactor added during self-splicing. This finding may have relevance to a prebiotic RNA world and to modern biology.
SUBMITTER: Vicens Q
PROVIDER: S-EPMC2897744 | biostudies-literature |
REPOSITORIES: biostudies-literature
ACCESS DATA