Ontology highlight
ABSTRACT:
SUBMITTER: Yi C
PROVIDER: S-EPMC2897962 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Yi Chunling C Maksimoska Jasna J Marmorstein Ronen R Kissil Joseph L JL
Biochemical pharmacology 20100317 5
The p21-activated kinases (PAKs), immediate downstream effectors of the small G-proteins of the Rac/cdc42 family, are critical mediators of signaling pathways regulating cellular behaviors and as such, have been implicated in pathological conditions including cancer. Recent studies have validated the requirement for PAKs in promoting tumorigenesis in breast carcinoma and neurofibromatosis. Thus, there has been considerable interest in the development of inhibitors to the PAKs, as biological mark ...[more]