Ontology highlight
ABSTRACT:
SUBMITTER: Mustafi SM
PROVIDER: S-EPMC2897963 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Biochemical and biophysical research communications 20100531 3
Abeta peptides aggregate to form insoluble and neurotoxic fibrils associated with Alzheimer's disease. Inhibition of the aggregation has been the subject of numerous studies. Here we describe a novel, substoichiometric inhibitor of Abeta(1-40) fibrillization as a tandem dimeric construct consisting of Abeta(40-1) (reverse sequence) linked to Abeta(1-40) via an eight residue glycine linker. At molar ratios of the tandem peptide to Abeta(1-40) of 1:10 to 1:25 inhibition of fibrillization, as measu ...[more]