HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients.
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ABSTRACT:
SUBMITTER: Skar H
PROVIDER: S-EPMC2898231 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients.
Skar Helena H Borrego Pedro P Wallstrom Timothy C TC Mild Mattias M Marcelino José Maria JM Barroso Helena H Taveira Nuno N Leitner Thomas T Albert Jan J
Journal of virology 20100512 14
The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter ge ...[more]
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