Ontology highlight
ABSTRACT:
SUBMITTER: Nagano M
PROVIDER: S-EPMC2898296 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20100503 27
Cell migration on an extracellular matrix (ECM) requires continuous formation and turnover of focal adhesions (FAs) along the direction of cell movement. However, our knowledge of the components of FAs and the mechanism of their regulation remains limited. Here, we identify ZF21, a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain, to be a new regulator of FAs and cell movement. Knockdown of ZF21 expression in cells increased the n ...[more]