Ontology highlight
ABSTRACT:
SUBMITTER: Donato DM
PROVIDER: S-EPMC2898362 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Donato Dominique M DM Ryzhova Larisa M LM Meenderink Leslie M LM Kaverina Irina I Hanks Steven K SK
The Journal of biological chemistry 20100429 27
The docking protein p130Cas is a major Src substrate involved in integrin signaling and mechanotransduction. Tyrosine phosphorylation of p130Cas in focal adhesions (FAs) has been linked to enhanced cell migration, invasion, proliferation, and survival. However, the mechanism of p130Cas targeting to FAs is uncertain, and dynamic aspects of its localization have not been explored. Using live cell microscopy, we show that fluorophore-tagged p130Cas is a component of FAs throughout the FA assembly a ...[more]