Ontology highlight
ABSTRACT:
SUBMITTER: Koike M
PROVIDER: S-EPMC2898386 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Koike Masaaki M Fukushi Junpei J Ichinohe Yuzuru Y Higashimae Naoki N Fujishiro Masahiko M Sasaki Chiyomi C Yamaguchi Masahiro M Uchihara Toshiki T Yagishita Saburo S Ohizumi Hiroshi H Hori Seiji S Kakizuka Akira A
The Journal of biological chemistry 20100421 28
Abnormal protein accumulation is often observed in human neurodegenerative disorders such as polyglutamine diseases and Parkinson disease. Genetic and biochemical analyses indicate that valosin-containing protein (VCP) is a crucial molecule in the pathogenesis of human neurodegenerative disorders. We report here that VCP was specifically modified in neuronal cells with abnormal protein accumulation; this modification caused the translocation of VCP into the nucleus. Modification-mimic forms of V ...[more]