Structure of autophagy-related protein Atg8 from the silkworm Bombyx mori.
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ABSTRACT:
SUBMITTER: Hu C
PROVIDER: S-EPMC2898461 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
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Structure of autophagy-related protein Atg8 from the silkworm Bombyx mori.
Hu Chen C Zhang Xuan X Teng Yan Bin YB Hu Hai Xi HX Li Wei Fang WF
Acta crystallographica. Section F, Structural biology and crystallization communications 20100623 Pt 7
Autophagy-related protein Atg8 is ubiquitous in all eukaryotes. It is involved in the Atg8-PE ubiquitin-like conjugation system, which is essential for autophagosome formation. The structures of Atg8 from different species are very similar and share a ubiquitin-fold domain at the C-terminus. In the 2.40 A crystal structure of Atg8 from the silkworm Bombyx mori reported here, the ubiquitin fold at the C-terminus is preceded by two additional helices at the N-terminus. ...[more]
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