Ontology highlight
ABSTRACT:
SUBMITTER: Garcia MR
PROVIDER: S-EPMC2898596 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Garcia Mercedes Rodriguez MR Ledgerwood Levi L Yang Yu Y Xu Jiangnan J Lal Girdhari G Burrell Bryna B Ma Ge G Hashimoto Daigo D Li Yansui Y Boros Peter P Grisotto Marcos M van Rooijen Nico N Matesanz Rafael R Tacke Frank F Ginhoux Florent F Ding Yaozhong Y Chen Shu-Hsia SH Randolph Gwendalyn G Merad Miriam M Bromberg Jonathan S JS Ochando Jordi C JC
The Journal of clinical investigation 20100614 7
One of the main unresolved questions in solid organ transplantation is how to establish indefinite graft survival that is free from long-term treatment with immunosuppressive drugs and chronic rejection (i.e., the establishment of tolerance). The failure to achieve this goal may be related to the difficulty in identifying the phenotype and function of the cell subsets that participate in the induction of tolerance. To address this issue, we investigated the suppressive roles of recipient myeloid ...[more]