Ontology highlight
ABSTRACT:
SUBMITTER: Chapman S
PROVIDER: S-EPMC2898606 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Chapman Sandra S Liu Xuefeng X Meyers Craig C Schlegel Richard R McBride Alison A AA
The Journal of clinical investigation 20100701 7
Primary human keratinocytes are useful for studying the pathogenesis of many different diseases of the cutaneous and mucosal epithelia. In addition, they can form organotypic tissue equivalents in culture that can be used as epidermal autografts for wound repair as well as for the delivery of gene therapy. However, primary keratinocytes have a finite lifespan in culture that limits their proliferative capacity and clinical use. Here, we report that treatment of primary keratinocytes (originating ...[more]