Dataset Information

Residential traffic exposure, pulse pressure, and C-reactive protein: consistency and contrast among exposure characterization methods.

ABSTRACT:

Background

Traffic exposure may increase cardiovascular disease (CVD) risk via systemic inflammation and elevated blood pressure, two important clinical markers for managing disease progression.

Objectives

We assessed degree and consistency of association between traffic exposure indicators as predictors of C-reactive protein (CRP) and pulse pressure (PP) in an adult U.S. Puerto Rican population (n = 1,017).

Methods

Cross-sectional information on health and demographics and blood data was collected. Using multiple linear regression, we tested for associations between CRP, PP, and six traffic exposure indicators including residential proximity to roads with > 20,000 vehicles/day and traffic density [vehicle miles traveled per square mile (VMT/mi2)]. Diabetes and obesity [body mass index (BMI) >or= 30 kg/m2] were tested as effect modifiers.

Results

CRP was positively associated with traffic density in the total population [36% CRP difference with 95% confidence interval (CI) 2.5-81%] for residence within the highest versus lowest VMT/mi2 level. With BMI >or= 30, CRP showed significant positive associations with five of six traffic indices including residence 200 m of a roadway [22.7% CRP difference (95% CI, 3.15-46.1)] and traffic density in the third highest versus lowest VMT/mi2 level [28.1% difference (95% CI, 1.0-62.6)]. PP was positively associated with residence within or= 30 [3.8 mmHg (95% CI, 0.88-6.8)]. Effect estimates approximately doubled for residence within ConclusionsTraffic exposure at roadway volumes as low as 20,000-40,000 vehicles/day may increase CVD risk through adverse effects on blood pressure and inflammation. Individuals with elevated inflammation profiles, that is, BMI >or= 30, may be more susceptible to the effects of traffic exposure.

SUBMITTER: Rioux CL

PROVIDER: S-EPMC2898857 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Publications

Residential traffic exposure, pulse pressure, and C-reactive protein: consistency and contrast among exposure characterization methods.

Rioux Christine L CL Tucker Katherine L KL Mwamburi Mkaya M Gute David M DM Cohen Steven A SA Brugge Doug D

Environmental health perspectives 20100202 6

<h4>Background</h4>Traffic exposure may increase cardiovascular disease (CVD) risk via systemic inflammation and elevated blood pressure, two important clinical markers for managing disease progression.<h4>Objectives</h4>We assessed degree and consistency of association between traffic exposure indicators as predictors of C-reactive protein (CRP) and pulse pressure (PP) in an adult U.S. Puerto Rican population (n = 1,017).<h4>Methods</h4>Cross-sectional information on health and demographics and ...[more]

PMID: 20123638

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Dataset Information

Residential traffic exposure, pulse pressure, and C-reactive protein: consistency and contrast among exposure characterization methods.

Background

Objectives

Methods

Results

Publications

Residential traffic exposure, pulse pressure, and C-reactive protein: consistency and contrast among exposure characterization methods.

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