Traffic-related air pollution and QT interval: modification by diabetes, obesity, and oxidative stress gene polymorphisms in the normative aging study.

ABSTRACT: Acute exposure to ambient air pollution has been associated with acute changes in cardiac outcomes, often within hours of exposure.We examined the effects of air pollutants on heart-rate-corrected QT interval (QTc), an electrocardiographic marker of ventricular repolarization, and whether these associations were modified by participant characteristics and genetic polymorphisms related to oxidative stress.We studied repeated measurements of QTc on 580 men from the Veterans Affairs Normative Aging Study (NAS) using mixed-effects models with random intercepts. We fitted a quadratic constrained distributed lag model to estimate the cumulative effect on QTc of ambient air pollutants including fine particulate matter

SUBMITTER: Baja ES 

PROVIDER: S-EPMC2898862 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature