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Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds.

ABSTRACT: In this paper, we demonstrate for the first time that the detailed cutaneous blood flow at capillary level within dermis of human skin can be imaged by optical micro-angiography (OMAG) technique. A novel scanning protocol, i.e. fast B scan mode is used to achieve the capillary flow imaging. We employ a 1310nm system to scan the skin tissue at an imaging rate of 300 frames per second, which requires only ~5 sec to complete one 3D imaging of capillary blood flow within skin. The technique is sensitive enough to image the very slow blood flows at ~4 microm/sec. The promising results show a great potential of OMAG's role in the diagnosis, treatment and management of human skin diseases.

SUBMITTER: An L

PROVIDER: S-EPMC2898895 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds.

An Lin L Qin Jia J Wang Ruikang K RK

Optics express 20100401 8

In this paper, we demonstrate for the first time that the detailed cutaneous blood flow at capillary level within dermis of human skin can be imaged by optical micro-angiography (OMAG) technique. A novel scanning protocol, i.e. fast B scan mode is used to achieve the capillary flow imaging. We employ a 1310nm system to scan the skin tissue at an imaging rate of 300 frames per second, which requires only ~5 sec to complete one 3D imaging of capillary blood flow within skin. The technique is sensi ...[more]

PMID: 20588668

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