Ontology highlight
ABSTRACT:
SUBMITTER: Rosendahl J
PROVIDER: S-EPMC2899151 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Rosendahl Jonas J Teich Niels N Kovacs Peter P Szmola Richard R Blüher Matthias M Gress Thomas M TM Hoffmeister Albrecht A Keim Volker V Löhr Matthias M Mössner Joachim J Nickel Renate R Ockenga Johann J Pfützer Roland R Schulz Hans-Ulrich HU Stumvoll Michael M Wittenburg Henning H Sahin-Tóth Miklós M Witt Heiko H
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20100513 2-3
<h4>Background/aims</h4>A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of chronic pancreatitis (CP). Mesotrypsin (PRSS3) can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for CP.<h4>Methods</h4>We analyzed all 5 exons and the adjacent non-coding sequences of PRSS3 by direct sequencing of 313 CP patients and 327 controls. Additionally, ...[more]