Ontology highlight
ABSTRACT:
SUBMITTER: Biertumpfel C
PROVIDER: S-EPMC2899710 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Biertümpfel Christian C Zhao Ye Y Kondo Yuji Y Ramón-Maiques Santiago S Gregory Mark M Lee Jae Young JY Masutani Chikahide C Lehmann Alan R AR Hanaoka Fumio F Yang Wei W
Nature 20100601 7301
The variant form of the human syndrome xeroderma pigmentosum (XPV) is caused by a deficiency in DNA polymerase eta (Poleta), a DNA polymerase that enables replication through ultraviolet-induced pyrimidine dimers. Here we report high-resolution crystal structures of human Poleta at four consecutive steps during DNA synthesis through cis-syn cyclobutane thymine dimers. Poleta acts like a 'molecular splint' to stabilize damaged DNA in a normal B-form conformation. An enlarged active site accommoda ...[more]