Gene promoter evolution targets the center of the human protein interaction network.

ABSTRACT: Assessing the contribution of promoters and coding sequences to gene evolution is an important step toward discovering the major genetic determinants of human evolution. Many specific examples have revealed the evolutionary importance of cis-regulatory regions. However, the relative contribution of regulatory and coding regions to the evolutionary process and whether systemic factors differentially influence their evolution remains unclear. To address these questions, we carried out an analysis at the genome scale to identify signatures of positive selection in human proximal promoters. Next, we examined whether genes with positively selected promoters (Prom+ genes) show systemic differences with respect to a set of genes with positively selected protein-coding regions (Cod+ genes). We fou

SUBMITTER: Planas J 

PROVIDER: S-EPMC2900212 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature