Ontology highlight
ABSTRACT:
SUBMITTER: Bishop MT
PROVIDER: S-EPMC2900653 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Bishop Matthew T MT Will Robert G RG Manson Jean C JC
Proceedings of the National Academy of Sciences of the United States of America 20100614 26
The biological determinants of the phenotypic variation in sporadic Creutzfeldt-Jakob disease (sCJD) are unknown. To categorize sCJD cases, the prion protein (PrP) codon 129 genotype and the biochemical characteristics of the disease-associated form of PrP (PrP(Sc)) can be combined to form six subgroups (MM1, MM2, MV1, MV2, VV1, and VV2). This classification largely correlates with the known variation in the clinical and pathological features of sCJD, with the MM1 and MV1 cases representing the ...[more]