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Conservation of progesterone hormone function in invertebrate reproduction.


ABSTRACT: Steroids play fundamental roles regulating mammalian reproduction and development. Although sex steroids and their receptors are well characterized in vertebrates and several arthropod invertebrates, little is known about the hormones and receptors regulating reproduction in other invertebrate species. Evolutionary insights into ancient endocrine pathways can be gained by elucidating the hormones and receptors functioning in invertebrate reproduction. Using a combination of genomic analyses, receptor imaging, ligand identification, target elucidation, and exploration of function through receptor knockdown, we now show that comparable progesterone chemoreception exists in the invertebrate monogonont rotifer Brachionus manjavacas, suggesting an ancient origin of the signal transduction systems commonly associated with the development and integration of sexual behavior in mammals.

SUBMITTER: Stout EP 

PROVIDER: S-EPMC2900687 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Conservation of progesterone hormone function in invertebrate reproduction.

Stout E Paige EP   La Clair James J JJ   Snell Terry W TW   Shearer Tonya L TL   Kubanek Julia J  

Proceedings of the National Academy of Sciences of the United States of America 20100614 26


Steroids play fundamental roles regulating mammalian reproduction and development. Although sex steroids and their receptors are well characterized in vertebrates and several arthropod invertebrates, little is known about the hormones and receptors regulating reproduction in other invertebrate species. Evolutionary insights into ancient endocrine pathways can be gained by elucidating the hormones and receptors functioning in invertebrate reproduction. Using a combination of genomic analyses, rec  ...[more]

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