Ontology highlight
ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC2901214 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Zhu Xiao X Li Dong-Pei DP Fan Wen-Guo WG Lin Marie C M MC Wang Jin-Long JL Lin Sheng-Qu SQ Huang Jian-Qing JQ Kung Hsiang-Fu HF
BMC medical genetics 20100602
<h4>Background</h4>Hepatitis B virus (HBV) infection causes large amount of unfolding or false-folding protein accumulation in the endoplasmic reticulum (ER), which in turn induces the expression of glucose-regulated protein 78 (GRP78). The aim in the present study was to analyse the potential association between GRP78 single-nucleotide polymorphisms (SNPs) and the risk of HBV infection.<h4>Methods</h4>The associations between seven common GRP78 polymorphisms in the promoter (rs391957, rs1784076 ...[more]