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Membrane potential is important for bacterial cell division.

ABSTRACT: Many cell division-related proteins are located at specific positions in the bacterial cell, and this organized distribution of proteins requires energy. Here, we report that the proton motive force, or more specifically the (trans)membrane potential, is directly involved in protein localization. It emerged that the membrane potential modulates the distribution of several conserved cell division proteins such as MinD, FtsA, and the bacterial cytoskeletal protein MreB. We show for MinD that this is based on the membrane potential stimulated binding of its C-terminal amphipathic helix. This function of the membrane potential has implications for how these morphogenetic proteins work and provide an explanation for the effects observed with certain antimicrobial compounds.

SUBMITTER: Strahl H

PROVIDER: S-EPMC2901462 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Membrane potential is important for bacterial cell division.

Strahl Henrik H Hamoen Leendert W LW

Proceedings of the National Academy of Sciences of the United States of America 20100621 27

Many cell division-related proteins are located at specific positions in the bacterial cell, and this organized distribution of proteins requires energy. Here, we report that the proton motive force, or more specifically the (trans)membrane potential, is directly involved in protein localization. It emerged that the membrane potential modulates the distribution of several conserved cell division proteins such as MinD, FtsA, and the bacterial cytoskeletal protein MreB. We show for MinD that this ...[more]

PMID: 20566861

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