Ontology highlight
ABSTRACT:
SUBMITTER: Carretero J
PROVIDER: S-EPMC2901842 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Carretero Julian J Shimamura Takeshi T Rikova Klarisa K Jackson Autumn L AL Wilkerson Matthew D MD Borgman Christa L CL Buttarazzi Matthew S MS Sanofsky Benjamin A BA McNamara Kate L KL Brandstetter Kathleyn A KA Walton Zandra E ZE Gu Ting-Lei TL Silva Jeffrey C JC Crosby Katherine K Shapiro Geoffrey I GI Maira Sauveur-Michel SM Ji Hongbin H Castrillon Diego H DH Kim Carla F CF García-Echeverría Carlos C Bardeesy Nabeel N Sharpless Norman E NE Hayes Neil D ND Kim William Y WY Engelman Jeffrey A JA Wong Kwok-Kin KK
Cancer cell 20100601 6
In mice, Lkb1 deletion and activation of Kras(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomic and proteomic profiles, and have identified gene and phosphoprotein signatures associated with Lkb1 loss and progression to invasive and metastatic lung tumors. These studies revealed that SRC is activated in Lkb1-deficient primary and metastatic lung tumors, and that the combi ...[more]