Ontology highlight
ABSTRACT:
SUBMITTER: Spyranti Z
PROVIDER: S-EPMC2902127 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Spyranti Zinovia Z Galanis Athanassios S AS Pairas George G Spyroulias Georgios A GA Manessi-Zoupa Evy E Cordopatis Paul P
Bioinorganic chemistry and applications 20100609
The rational design of synthetic peptides is proposed as an efficient strategy for the structural investigation of crucial protein domains difficult to be produced. Only after half a century since the function of ACE was first reported, was its crystal structure solved. The main obstacle to be overcome for the determination of the high resolution structure was the crystallization of the highly hydrophobic transmembrane domain. Following our previous work, synthetic peptides and Zinc(II) metal io ...[more]