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Transformative effects of higher magnetic field in Fourier transform ion cyclotron resonance mass spectrometry.


ABSTRACT: The relationship of magnetic field strength and Fourier transform ion cyclotron resonance mass spectrometry performance was tested using three instruments with the same design but different fields of 4.7, 7, and 9.4 tesla. We found that the theoretically predicted "transformative" effects of magnetic field are indeed observed experimentally. The most striking effects were that mass accuracy demonstrated approximately second to third order improvement with the magnetic field, depending upon the charge state of the analyte, and that peak splitting, which prohibited automated data analysis at 4.7 T, was not observed at 9.4 T.

SUBMITTER: Karabacak NM 

PROVIDER: S-EPMC2902155 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Transformative effects of higher magnetic field in Fourier transform ion cyclotron resonance mass spectrometry.

Karabacak N Murat NM   Easterling Michael L ML   Agar Nathalie Y R NY   Agar Jeffrey N JN  

Journal of the American Society for Mass Spectrometry 20100331 7


The relationship of magnetic field strength and Fourier transform ion cyclotron resonance mass spectrometry performance was tested using three instruments with the same design but different fields of 4.7, 7, and 9.4 tesla. We found that the theoretically predicted "transformative" effects of magnetic field are indeed observed experimentally. The most striking effects were that mass accuracy demonstrated approximately second to third order improvement with the magnetic field, depending upon the c  ...[more]

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