Ontology highlight
ABSTRACT:
SUBMITTER: Lutolf MP
PROVIDER: S-EPMC2902161 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Lutolf Matthias P MP Doyonnas Regis R Havenstrite Karen K Koleckar Kassie K Blau Helen M HM
Integrative biology : quantitative biosciences from nano to macro 20081121 1
Hematopoietic stem cells (HSCs) are capable of extensive self-renewal in vivo and are successfully employed clinically to treat hematopoietic malignancies, yet are in limited supply as in culture this self-renewal capacity is lost. Using an approach at the interface of stem cell biology and bioengineering, here we describe a novel platform of hydrogel microwell arrays for assessing the effects of either secreted or tethered proteins characteristic of the in vivo microenvironment, or niche, on HS ...[more]