ARC synergizes with ABT-737 to induce apoptosis in human cancer cells.
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ABSTRACT:
SUBMITTER: Bhat UG
PROVIDER: S-EPMC2902270 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
ARC synergizes with ABT-737 to induce apoptosis in human cancer cells.
Bhat Uppoor G UG Pandit Bulbul B Gartel Andrei L AL
Molecular cancer therapeutics 20100601 6
Previously, we reported that the nucleoside analogue/transcriptional inhibitor ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)-pyrimidine-5-carboxamide) was able to induce p53-independent apoptosis in multiple cancer cell lines of different origins. This occurred, at least in part, by the suppression of short-lived, prosurvival member of the Bcl-2 family, Mcl-1. In contrast, we show here that treatment of human cancer cells with the pan-Bcl-2 inhibitor ABT-737 alone led to upre ...[more]
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