Ontology highlight
ABSTRACT:
SUBMITTER: Milne TA
PROVIDER: S-EPMC2902588 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Milne Thomas A TA Kim Jaehoon J Wang Gang G GG Stadler Sonja C SC Basrur Venkatesha V Whitcomb Sarah J SJ Wang Zhanxin Z Ruthenburg Alexander J AJ Elenitoba-Johnson Kojo S J KS Roeder Robert G RG Allis C David CD
Molecular cell 20100610 6
MLL1 fusion proteins activate HoxA9 gene expression and cause aggressive leukemias that respond poorly to treatment, but how they recognize and stably bind to HoxA9 is not clearly understood. In a systematic analysis of MLL1 domain recruitment activity, we identified an essential MLL1 recruitment domain that includes the CXXC domain and PHD fingers and is controlled by direct interactions with the PAF elongation complex and H3K4Me2/3. MLL1 fusion proteins lack the PHD fingers and require prebind ...[more]