Ontology highlight
ABSTRACT:
SUBMITTER: Na H
PROVIDER: S-EPMC2902707 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Na Hong H Huisman Willem W Ellestad Kristofor K KK Phillips Tom R TR Power Christopher C
Virology 20100608 2
Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA). To examine the role of the RNA secondary structure of the RRE, mutational analyses were performed in both an infectious FIV molecular clone and a FIV CAT-RRE reporter system. These studies disclosed that the stems within SLA (SA1, 2, 3, 4, and 5) of the RRE we ...[more]