Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
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ABSTRACT:
SUBMITTER: Boonstra JJ
PROVIDER: S-EPMC2902814 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
Boonstra Jurjen J JJ van Marion Ronald R Beer David G DG Lin Lin L Chaves Paula P Ribeiro Catarina C Pereira A Dias AD Roque Lúcia L Darnton S Jane SJ Altorki Nasser K NK Schrump David S DS Klimstra David S DS Tang Laura H LH Eshleman James R JR Alvarez Hector H Shimada Yutaka Y van Dekken Herman H Tilanus Hugo W HW Dinjens Winand N M WN
Journal of the National Cancer Institute 20100114 4
For decades, hundreds of different human tumor type-specific cell lines have been used in experimental cancer research as models for their respective tumors. The veracity of experimental results for a specific tumor type relies on the correct derivation of the cell line. In a worldwide effort, we verified the authenticity of all available esophageal adenocarcinoma (EAC) cell lines. We proved that the frequently used cell lines SEG-1 and BIC-1 and the SK-GT-5 cell line are in fact cell lines from ...[more]
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