Ontology highlight
ABSTRACT:
SUBMITTER: Sakuma M
PROVIDER: S-EPMC2903214 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Sakuma Masashi M Morooka Toshifumi T Wang Yunmei Y Shi Can C Croce Kevin K Gao Huiyun H Strainic Michael M Medof M Edward ME Simon Daniel I DI
Arteriosclerosis, thrombosis, and vascular biology 20100318 6
<h4>Objective</h4>To investigate whether the presence of decay-accelerating factor (or CD55), an intrinsic complement regulator, protects against the development of vascular disease, given that complement activation can affect leukocytes and platelets.<h4>Methods and results</h4>Leukocyte-platelet complexes are critical for the initiation and progression of atherosclerosis and restenosis; however, the mechanism by which these processes promote vascular injury is incompletely defined. We performe ...[more]