Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez R
PROVIDER: S-EPMC2903397 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Sánchez Ricardo R Pantoja-Uceda David D Prieto Jesús J Diercks Tammo T Marcaida María J MJ Montoya Guillermo G Campos-Olivas Ramón R Blanco Francisco J FJ
The Journal of biological chemistry 20100511 29
Gadd45alpha is a nuclear protein encoded by a DNA damage-inducible gene. Through its interactions with other proteins, Gadd45alpha participates in the regulation of DNA repair, cell cycle, cell proliferation, and apoptosis. The NMR structure of human Gadd45alpha has been determined and shows an alpha/beta fold with two long disordered and flexible regions at the N terminus and one of the loops. Human Gadd45alpha is predominantly monomeric in solution but exists in equilibrium with dimers and oth ...[more]