Ontology highlight
ABSTRACT:
SUBMITTER: Manna SK
PROVIDER: S-EPMC2903425 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Manna Sunil K SK Bose Julie S JS Gangan Vijay V Raviprakash Nune N Navaneetha Thota T Raghavendra Pongali B PB Babajan Banaganapalli B Kumar Chitta S CS Jain Swatantra K SK
The Journal of biological chemistry 20100514 29
The Dracaena resin is widely used in traditional medicine as an anticancer agent, and benzofuran lignan is the active component. In this report, we provide evidence that the synthetic derivative of benzofuran lignan (Benfur) showed antitumor activities. It induced apoptosis in p53-positive cells. Though it inhibited endotoxin-induced nuclear factor kappaB (NF-kappaB) activation in both p53-positive and -negative cells, the activation of caspase 3 was observed in p53-positive cells. It showed par ...[more]